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Domperidone for breast milk

Domperidone is an antiemetic and prokinetic drug, which acts by blocking dopamine receptors in the gastrointestinal tract wall and the chemoreceptor trigger zone in the brainstem. This peripheral blockade of dopamine results in the release of prolactin from the pituitary, which in turn contributes to the production of breastmilk. Hyperprolactinaemia, and in some cases subsequent galactorrhea is thus a known side effect of domperidone, which is sometimes exploited to increase milk production in mothers whose milk supply is diminishing. Importantly, domperidone does not cross the blood brain barrier and so does not affect the actions of dopamine in the central nervous system, giving it a more favourable side effect profile than some other comparable agents. To provide a guideline for health professionals on the use of domperidone as a galactogogue for mothers with a faltering milk supply. An Information Sheet is to be provided to mothers on the use of domperidone see toolbar.
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Galactagogues (substances claimed to increase supply)

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Domperidone - Wikipedia

There are several prescription drugs that have been used to increase milk supply: Metoclopramide Reglan , Domperidone Motilium , and sulpiride Eglonyl, Dolmatil, Sulpitil, Sulparex, Equemote. The presence of an appropriate level of the hormone prolactin permits lactation to proceed normally. When a mother has low prolactin levels, milk supply may be affected. Prolactin levels are primarily regulated by inhibition : the presence of prolactin-inhibiting factors dopamine is the principal one keep prolactin levels in check. The drugs used for increasing milk supply work by blocking dopamine, which results in an increase in prolactin levels.
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Enhancing Breast Milk Production With Domperidone in Mothers of Preterm Neonates (EMPOWER)

HealthDay —Domperidone is well tolerated and effective in producing a moderate short-term increase in expressed breast milk volume among mothers of preterm infants, according to a review published online Feb. Luke E. Grzeskowiak, Ph.
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By Jessica Leeder Jan 8, Photo: Roberto Caruso, watercolour: Claire Roskey. Prescribed to me by my midwife at the low dose of 10 milligrams three times per day, this glorious little white pill promised to take the edge off a worry that gnawed at me around the clock until my mind, too, felt raw: Was I making enough milk to satiate my baby boy? Or, as time ticked on, was I marching us both toward another sleepless night filled with bawling, cluster feeding, sack-like empty breasts and enough salty tears to drown us both? The worry would begin each day when I awoke, and it grew with every hour, sucking at my already low energy.

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